UV-Visible Spectrophotometer Do’s And Don’ts

Multiple instruments are used in pharmaceuticals. The UV-Visible spectrophotometer is one of the widely used instrument in the pharmaceutical quality control department.

There are some do’s and don’ts for all instruments, likewise UV-visible Spectrophotometer do’s and don’ts are there.

UV-Visible Spectrophotometer Do’s And Don’ts:

UV-Visible Spectrophotometer Do’s:

  1. Ensure the instrument is clean before use, including the surrounding area.
  2. Check the calibration status of the instrument before proceeding for analysis.
  3. Switch the correct wavelength in photometric mode as defined in the standard testing procedures (STP)
  4. Select the mode (Photometric or Spectrum) as per the defined procedure in STP and check for…

SOP for Handling Of Rejected Batches In Pharma Industry

Every organization is having its own SOP on the handling of rejected batches. Let’s understand common practices are followed by the organizations.

1. Objective

To lay down a procedure for initiation and approval of batch rejection note along with transfer of rejected batch from production/quarantine area in finished goods WH to scrap hold area in production / rejected batch hold area in the warehouse.

2. Scope

This procedure is applicable for the pilot, clinical, exhibit and commercial batches rejected at formulation.

3. Responsibilities

QA- For initiation of batch rejection note and paste rejected label on rejected batch container/shipper.

Production- To…


What Is A Significant Change In Stability

A significant change instability is a deviation from its trend. According to ICH guidelines, the remarkable changes observed in the drug product considered significant changes.

Definition of Significant change:

Significant change is a remarkable change in the physical or chemical properties of the drug product or drug substance. Or

It is a noticeable change in the physical or chemical property from its initial results of the drug product or drug substance.

What is a Significant change in Dissolution?

The significant change in dissolution is, when the dissolution does not meet (Fails) to S2 stage acceptance criteria then it is considered as a significant change.

What is ICH and FDA guidelines talks on What Is A Significant Change In Stability?

  1. A 5% change in assay from its…

Generally, this question comes to mind of every pharma person working in the industry. So, what is the exact meaning of these forms lets understand this through this article.

What Is Form 482–483 And 484 In Pharmaceuticals.

What is FDA Form 482?

FDA’s form 482 is one of the form used in the pharma industry. FDA form 482 is used to notify the manufacturing site for audit before it happening.

FDA form 482 is called a Notice of inspection form.

As per food and Drug cosmetic act section no. 704A-1, it is mention that USFDA has to inform before the inspection to the manufacturing unit for audit through FDA’s form 482.

What is FDA Form 483?

FDA’s form…


In this article, we will understand the disintegration test interview questions and answers. Quality control having multiple instruments and types of equipment, today we will understand the disintegration instrument and its purpose.

The interview is an opportunity if you take it positively or in simple words the person who wants to grow in his carrier is always ready for challenges and the others always ready with justification.

The interview is a part of the selection procedure of a candidate in any organization, it may be a private or government organization.

The interview is a procedure to judge the knowledge and…


7 QC tools are used to identify them and fix the problem with respect to product quality. It is a systematic and scientific problem-solving approach.

These 7 QC tools are easy to understand and it is a very good method to gather the information for product quality defects and for improvements way forward. It is a graphical presentation of the data. Let’s understand the 7 QC Tools Used For Process Improvement.

7 QC Tools Used For Process Improvement in pharma

This is a list of 7 QC tools that are used to improve the product quality and removal of defects.

  1. Cause and Effect Diagram (Fishbone or Ishikawa Diagram)
  2. Pareto…

Gas chromatography interview questions and answers are somewhere kept us on backfoot while interview. In this article we will try to cover such Gas chromatography interview question.

Gas Chromatography Interview Questions And Answers:

Question 1: What is GC full form?

Answer: GC full form is Gas Chromatography.

Question 2: What are the types of Gas Chromatography?

Answer: There are two types of Gas chromatography;

  1. Gas-Solid chromatography (GSC)
  2. Gas-liquid chromatography (GLC)

Question 3: What is gas solid chromatography?

Answer: In gas-solid chromatography, Gas acts as a mobile phase and salid as a stationary phase hence called gas-solid chromatography.

Question 4: What is USP General Chapter for Gas…


Karl Fischer titrator is one of the instrument in the quality control laboratory which is used to determine the water content/moisture content of the sample. The operation of the Karl Fischer apparatus plays a major role to generate an accurate result of % water content present on the sample.

Proper operation of Karl Fischer apparatus is important to as well as proper cleaning and precaution while handling of Karl Fischer apparatus is also important for the water content determination.

What is the operation of the Karl Fischer apparatus procedure?

Safety Precautions while Karl Fischer titration:

  1. Wear gloves, nose mask, and goggles while handling of Karl Fischer apparatus.
  2. Do not drain the waste of kf reagent directly…

In this article we will understand the disintegration test interview questions and answers. Quality control having multiple instruments and equipments, today we will understand disintegration instrument and it’s purpose.

Interview is an opportunity if you take it positive or in simple word the person who wants to grow in his carrier is always ready for challenges and the others always ready with justification.

Interview is a part of selection procedure of a candidate in any organization, it may be private or government organization.

Interview is a procedure to judge a knowledge and behavior of candidate within short period of time.


In the pharmaceutical industry, multiple terminologies are being used. Here we will understand the definition of pharmaceutical terms and dosage forms.

The pharmaceutical industry is a manufacturer of multiple dosage forms like as Solid oral, Liquid oral, Nasal spray, Eyedrop, Respules and various other forms.

Definition of pharmaceutical terms and dosage forms:

  1. Definition of Quality Assurance
  2. Definition of Quality Control
  3. Definition of Qualification
  4. Definition of Validation
  5. Definition of Calibration
  6. Definition of Standardization
  7. Definition of Standard operating procedure
  8. Definition of Quality management system
  9. Definition of Tablet
  10. Definition of Capsule
  11. Definition of Oral Liquid
  12. Definition of Nasal Spray
  13. Definition of Eye drop
  14. Definition of Oral Drops
  15. Definition of Respules

Pharmabeej

Part Time Blogger

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